In 1896, the All-Russian Industrial and Art Exhibition took place in Nizhny Novgorod, after which a branch of the Technical Society was established in the city. It took on the project of a railway between Nizhny Novgorod and Kazan. To avoid building a bridge over the Oka River, the tracks were decided to be laid along the riverbank terrace. The site for the station was chosen on the right bank of the Oka, opposite the Moscow Station, near the Degtyarev and Bashkirov mills.

Construction of the station took place from 1900 to 1904 under the guidance of Grigory Budagov, with the participation of the Moscow-Kazan Railway Company. The famous photographer Maxim Dmitriev captured the appearance of the new station.

Initially, the station was named after the village of Romodanovo in Mordovia, associated with the Romodanovsky princes. In the 1930s, it was renamed first to Arzamas and then, when trains began to run to Kazan, to Kazan Station.

Until 1945, the station belonged to the Moscow-Kazan Railway, then it came under the management of the Gorky Railway. The track passed through a dangerous mountainous area where landslides frequently occurred. To prevent them, drainage tunnels were manually drilled, the deepest of which reached 1.5 kilometers.

In 1961, the Sartakovsky railway bridge was built over the Oka, and long-distance trains began to run through it to the Moscow Station. Kazan Station became suburban, and part of its premises was allocated for training railway students.

In February 1974, due to landslides, the railway from the Miza station to Kazan Station was closed, and the Romodanovo station was shut down. The track in this section was dismantled, and the station building began to fall into disrepair. First, the students left, then the workers.

In 1993, the station building was recognized as an architectural monument, but it continued to deteriorate. In 2003, the company 'Novakard' purchased it and invested about a million dollars in its restoration. The reconstruction was led by Viktor Zubkov, using Dmitriev's photographs and old blueprints. The dome was remodeled three times to match the original. That same year, 'Novakard' moved into the station building. The authors of the reconstruction received a bronze diploma at the international festival 'Architecture-2005.'