In 1859 and 1861, country houses were built near the dacha of Princess Zinaida Yusupova by Franz Petrovich Devien, a lieutenant of the Imperial Guard Tsarskoye Selo Rifle Battalion and a participant in the defense of Sevastopol. Later, one of these buildings was acquired by merchant Dmitry Alexeyevich Drozhzhin, who was a hereditary honorary citizen.

Since Drozhzhin had no children, he made a will stating that all his property would pass to his wife Maria Alexandrovna, but without the right to sell. She could only use the real estate and the income from the capital of 1.15 million rubles. After her death, the property was to be sold, and the money given to the Empress for charity.

By 1904, the interest on the capital had significantly increased, and Maria Drozhzhina decided to build a charitable institution on her land. It was to include a maternity home, a children's craft shelter, and a church. The architect chosen was Silvio Danini.

Although Drozhzhina formally had no right to build on the land since she did not own it, the Palace Administration did not object, likely due to interest in the project. In 1905, a plot of the Separate Park was allocated for construction. However, the initial project was not realized.

In 1906, Danini created a new, more modest project, and construction began. The maternity home named after M.A. Drozhzhina opened on January 8, 1907. It accepted poor residents of Tsarskoye Selo and the surrounding areas for free, providing free gynecological consultations and medicines. The shelter could accommodate up to 1,000 births per year.

In 1909, a new building for the craft shelter was started according to Danini's project, connected to the maternity home by a gallery. It was planned that about 40 children would live there, but the building was never opened.

After Maria Drozhzhina's death in 1910, merchant A.M. Treblov took over the management. In 1916, a project for a new Mother and Child House was approved, but construction did not begin. In 1918, the shelter was renamed the Detskoselsky Institute for the Protection of Motherhood and Infancy, and the church was closed in 1923. Before the war, the building housed a sanatorium for children with tuberculosis.

Today, the building has been preserved, except for the dome, which was demolished during the Soviet era. The church's premises now house a dining room, and wooden beams remain in the bell tower. An historical fence is located on the side of Pavlovsky Highway. The building currently houses the Pushkin Anti-Tuberculosis Dispensary.