In the 18th century, most of the plots on the right side of Pomarancev Lane belonged to the Trubetskoy family. In 1907, plot No. 6 was acquired by N.N. Medyntsev, a hereditary honorary citizen and successful merchant who was passionate about collecting porcelain, paintings, and furniture. He decided to build a mansion suitable for displaying his collection and commissioned a project from the famous Moscow architect F.F. Voskresensky.

After clearing the plot, construction began on a stone two-story mansion, partially three stories on the courtyard side, with a basement floor along Troitsky Lane and a one-story stone porch along the northwest boundary. The house was completed in 1909.

Experts note its resemblance to the facade of a rental house in Paris, built in 1903 by architect Charles Klein, which can be explained by the fact that Medyntsev had an apartment in Paris.

The mansion on Pomarancev Lane is asymmetrical, characteristic of the Art Nouveau style. The right part of the facade, with a projection, is shorter than the left and richly decorated with ornamental elements, while the left part is longer and more restrained. The main entrance was located at the corner of the building. The architect used a variety of decor: window frames, small columns, and stucco. The facade is adorned with a bright mosaic panel depicting plants above the entrance arch.

The facades feature windows of various shapes and sizes, decorated with figurative attics and wrought iron grilles on the roof. The architraves above the first-floor windows contain bas-reliefs depicting thistles, which some researchers associate with Scottish motifs. Above the upper floor windows runs a frieze of dark turquoise majolica.

Of interest are the heraldic shield on the corner attic and the wrought iron flag holders on the ceramic cladding of the facade near the main entrance.

Initially, the house was painted turquoise, later it was repainted pale yellow. A light lattice fence in the Art Nouveau style is installed in front of the facade, while most of the plot is enclosed by a stone wall from the mid-20th century.

In 1919, Medyntsev's mansion briefly housed the 'IV Proletarian Museum,' where Medyntsev's collection was exhibited. It then hosted the Nansen Mission, the French Embassy, the Brain Institute, and the apartment of the Chairman of the Council of Ministers of the USSR G.M. Malenkov. From the late 1950s until the early 1970s, the mansion served as the residence of the Cuban ambassador and then the Embassy of Guinea.