In the early 19th century, the estate of General Glazova was located at the corner of Smolensky Boulevard and Glazovsky Lane. In 1879, a new mansion was built on its site, designed by architect Alexander Ivanovich Rezанов, known for his works in St. Petersburg and Moscow. The mansion was erected for tea merchant K.S. Popov, who was the first to establish tea plantations in the Caucasus. The building and its interiors are done in the 'neoclassical' style, including a Pompeian living room and an Empire-style hall.

In 1894, the mansion was reconstructed by architect Viktor Alexandrovich Mazyryin for the new owner, manufacturer Mikhail Abramovich Morozov. The house, located deep within the courtyard, is connected to two-story wings. The interiors represent a mix of various styles: an Egyptian entrance with sphinxes and Eastern patterns in the living room. There was also a collection of paintings by Morozov.

In 2019, the restoration of the mansion's facades was completed. The facades and stucco decor were cleaned, sculptures and architectural elements were restored. The lost decor of the mezzanine with lion heads was recreated on the western facade. The historical appearance was returned to the downspouts and cornices. The facade was painted turquoise. The mansion became a laureate of the 'Moscow Restoration-2020' competition.

The artist V.A. Serov often visited the mansion, painting a portrait of the house's owner. After Morozov's death, the house passed to his widow Margarita Kirillovna, where Moscow intelligentsia gathered. Alexander Scriabin, Leonid Sobinov, and Andrei Bely visited here. In the early 20th century, the mansion belonged to the Ushkov manufacturers, and after nationalization, it housed the October Revolution Club, then the district party committee, and a branch of the House of Pioneers.