The two-story mansion in the Empire style with a mezzanine was built after the fire of 1812 in the 1830s on land owned by state councilor D. A. Bezobrazov. In 1875-1878, architect A. L. Ober reconstructed it for the new owner, merchant E. E. Kartashev. In the 1880s, the house was acquired by Moscow merchant and honorary citizen A. I. Lyzhin, co-owner of the trading house "Lyzhin Iv. and Sons," which traded cloth on Ilyinka. Lyzhin also owned a cloth factory in the village of Ivanteevka near Moscow. He was a typical representative of the merchant class, as described in the works of A. N. Ostrovsky. In addition to the owner and his family, the house housed servants, clerks, and shop boys. In the basement, there was a large safe with three doors, as Lyzhin did not trust banks. The territory included a garden with various buildings where married daughters lived. Alexander Ivanovich established a strict daily routine and kept all the keys with him. After his death in 1900, his sons divided the inheritance.

The house on Ostozhenka and the textile factory in Ivanteevka went to the younger son, Vladimir Alexandrovich. At that time, the neighboring plot was acquired by architect L. N. Kekushev, a representative of Moscow modernism, and Lyzhin commissioned him to reconstruct the house.

Kekushev altered the facade and added single-story extensions. The facade decor is done in the modern style with lush stucco above the first-floor windows. The windows are adorned with sandriks and cartouches characteristic of Kekushev. The second-floor windows are simpler, with scrolls and shells. The cornice is supported by lions on dentils, and the mezzanine window is decorated with a female head. The interior designs are executed in various styles, with an abundance of wood.

The collaboration between Lyzhin and Kekushev continued, and the architect completely reconstructed the cloth factory in Ivanteevka, creating a beautiful production complex that remains a landmark to this day.

After the revolution, the mansion housed a kindergarten for a long time, which damaged the interiors. Now only the ceiling decor of the first-floor living room with stencil painting and a bright frieze with flowers has survived.

The mansion is privately owned, and its owner, passionate about Kekushev's work, has restored all the preserved details and recreated the lost ones. The original interiors have practically not survived, so elements from other buildings by Kekushev, such as the Bykov tenement house, "Metropol," and the Morozov house on Prechistenka, were used. The facade decor was recreated based on a preserved fragment.