The building was erected in 1876 at the request of Anna Vasilyevna Lopatina, a businesswoman and the wife of an honorary citizen of Moscow. The project was developed by the famous Moscow architect A. S. Kaminsky.

The Lopatina House is considered one of the first examples of "Russian style" in urban civil architecture. The main facade, adorned with multicolored ceramic tiles, the decor around the windows, as well as the fence and gates made of patterned metal, preserved in their original form, represent special architectural and artistic value.

Against the backdrop of a "carpet" geometric pattern, large windows on the second floor stand out, framed by casings. The upper floor is decorated with keel-shaped arches, which resonate with the monumental arcade at the base of the building. The house is crowned with a traditional "tent."

Initially, the building had only two floors. The architect proposed an original solution to Lopatina: to combine personal apartments, an office, rental housing, and storage in one building. The basement housed storage rooms and refrigerators, as the owner was engaged in supplying oysters and mussels to Moscow restaurants. The first floor contained the office, while the second housed the owner's apartments and rental units. A wing was added to the house, and a large garden with a pond sprawled towards Malaya Nikitskaya. Later, a third floor was added, executed in strict accordance with the original style. The windows of the third floor are united by a decorative motif reminiscent of a "kokoshnik."

In the early 20th century, the house was divided into apartments for rent. Around 1925, it became a dormitory for the veterans of the Bolshevik society. Since 1963, the building has housed the Embassy of Brazil. The interior of the house draws special attention to the vaulted ceiling of the music hall and the landscape wallpaper in the dining room, which was pasted up by the decision of the Government of Brazil over 30 years ago and is still in excellent condition.