The Orlov Regional Museum is located on the second floor of an ancient merchant mansion, which is part of a manor and park ensemble. This ensemble includes a two-story stone building with a mezzanine, a one-story wing connected to the main building by an archway, and a linden park. The ensemble is situated at the highest point in the city. The first owner of the building was Mitrofan Ivanovich Sintsov, a first-guild merchant and city mayor. This unique building hosted ceremonial receptions for distinguished guests, including Tsar Alexander I in 1824 and Tsarevich Alexander, the future Emperor Alexander II, who traveled accompanied by poet V.A. Zhukovsky and historian K.I. Arsenyev.

The next owner of the house was Alexander Nazaryevich Kuznetsov, a second-guild merchant. He was a highly educated and progressive figure, a patron of many institutions not only in Oryol but also in the provincial city of Vyatka. Kuznetsov headed the committee of the city public library, was an honorary justice of the peace, and served as city mayor for 25 years.

Currently, the museum includes four halls. The "19th Century Hall" features an 18th-century baroque furniture set, 19th-century furniture, 19th-century console clocks, and wall clocks from the Swiss company "Moser & Co" from the early 20th century. Here, one can also see antique writing instruments, dishes, and clothing of clergymen from the destroyed churches of the city. The "History Hall" introduces visitors to the life of the county and district in the 20th century, telling about the development of healthcare, education, industry, and agriculture. It showcases boxes inlaid with straw and products made of juniper by the honored cultural worker G.A. Kyrchanov. Special attention is given to the folk theater and the nature department. The "Hall of Glory" stores orders, medals of combat participants and rear workers, photographs, documents, personal belongings, and weapons that tell the story of the Great Patriotic War. A separate corner is dedicated to participants of military actions in Afghanistan and Chechnya. The "Exhibition Hall" hosts thematic and personal exhibitions.

The museum also has a "Peasant Life" section, where items of peasant life from the 19th and 20th centuries are presented.