The Karachev Odrin Men's Monastery, dedicated to Saint Nicholas, was founded in the early 15th century at the site of the miraculous appearance of the image of Saint Nicholas. The first mention of the Odrin Monastery appears in a state charter composed by the nun Eupraxia, daughter of the Lithuanian prince Olgerd, who was the abbess of a nearby women's monastery. In this charter, she transferred part of her lands to the Odrin wilderness. In 1697, His Holiness Patriarch Adrian confirmed the foundation of the monastery. The period of the monastery's flourishing occurred during the management of Abbot Varnafa (1705-1720), when a stone church in honor of the icon of the Mother of God "The Sign" with a bell tower and the Nicholas Cathedral were built, replacing the wooden church.

The previously little-known Odrin wilderness became a place of pilgrimage. However, in 1764, the monastery was recognized as non-staff and remained in decline for a long time. The monastery reached its greatest glory under Abbot Serapion (1834-1856), who had previously labored in the Belo-Berezhskaya Wilderness under the guidance of the famous disciples of the Venerable Elder Paisius Velichkovsky. Abbot Serapion significantly improved the spiritual and external condition of the monastery. In 1843, the miraculous icon of the Mother of God "Intercessor of Sinners" was glorified here. One of the last superiors, Archimandrite Theodosius, was actively engaged in economic activities: during his tenure, a brick factory was built, a fence 17 km long was erected, a two-story hotel was constructed, ponds were created, and a Sunday school was opened in the village of Odrino. By the time of the monastery's closure, there were more than seventy brick buildings.

In 1922, a children's colony was placed on the territory of the monastery, and later, a military training ground of the Western Front. In 1924, the monastery was officially closed, and many monks found refuge in the churches of Karachev. In 1930, six monks along with the former superior, Bishop Agapit, were convicted under Article 58. The churches gradually fell into ruin, and the authorities decided to dismantle the bell tower in 1928 and the five-altar cathedral in 1930. To this day, only two buildings from the mid-19th century remain: the abbot's house and the brotherhood building. During the war, these buildings housed the German headquarters, and after the war, a children's home and school. In 1970, the children's home was closed, and for some time, a recreation base for a sewing factory was located here. 10-12 years before the monastery's reopening, the buildings were abandoned and on the verge of destruction.

On July 22, 1995, the Odrin Women's Monastery in honor of Saint Nicholas was opened at the site of the destroyed monastery, with Abbess Mariam (Shagarova) as its head. Currently, the monastery houses the miraculous icon of the Mother of God "Intercessor of Sinners." In 2004, a newly built church in honor of this holy image was consecrated.