The first wooden church in the village of Glazovskaya was built in 1750 with funds from newly converted Udmurts by the decree of the Holy Synod dated April 3, 1747. It was consecrated in the name of the Ascension of the Lord with an altar in honor of Saint Nicholas the Wonderworker. At the same time, a parish was established, and the village of Glazovskaya became a selo.

In 1786, the Vyatka Spiritual Consistory issued a permit for the construction of a stone church to replace the old wooden one. The church was built with funds from parishioners and the widow Feokla Koreneva from Slobodskoy. Construction was completed in 1793, and the main altar was consecrated in honor of the Transfiguration of the Lord on December 7, 1798. The altars in honor of Nicholas the Wonderworker and Saint Isidore of Pelusium were consecrated in September 1794.

Since 1801, the Transfiguration Church became a cathedral. In 1809, a bell tower was added, and in 1817, with funds from parishioners, a church was established in it in the name of the Ascension of the Lord. In 1859, a warm church with two altars was added to the bell tower: in honor of the Mother of God "Joy of All Who Sorrow" and Nicholas the Wonderworker. The iconostasis was arranged by Grigory Sergeyev.

In 1859, the Ascension Church was considered one of the altars of the warm church. In 1875, the cold church was dismantled. A new temple was built in 1879 but collapsed due to improper dome construction.

In 1887, the temple was restored with three altars. In the basement, a cave church was established in honor of Saint Isidore of Pelusium, consecrated on July 8, 1893. The main altar in honor of the Transfiguration of the Lord was consecrated on July 18, 1894. The altar in honor of the Mother of God of Chernigov, built with funds from merchant Pyotr Vasilyev, was consecrated on June 21, 1896. The left altar is dedicated to the Holy Prophet Elijah.

By 1913, the cathedral had seven altars. In the new church, the altar in honor of the Transfiguration of the Lord was consecrated on July 18, 1894, in honor of the Prophet Elijah on September 3, 1905, and in honor of the Chernigov Icon of the Mother of God on June 21, 1896. In the basement, the cave church in honor of Isidore of Pelusium was consecrated on July 8, 1883. In the old church, the altars in honor of Nicholas the Wonderworker and the icon of the Mother of God "Joy of All Who Sorrow," as well as the altar of the Ascension of the Lord in the bell tower.

In 1865, a church-parish guardianship was established at the cathedral. Three churches were attached to the cathedral: a house church of the prison castle in honor of the Holy Guardian Angel, built in 1872, a cemetery church in honor of the Descent of the Holy Spirit upon the Apostles, built in 1848, and the City Church in honor of Saint George the Great Martyr, built in 1902 and closed in 1929.

Two chapels were built in the cathedral parish. One in memory of the visit of the heir to the throne to the city in 1873 and his death in 1890, the other in memory of the refusal of the Votyaks from pagan rituals and the salvation of Emperor Alexander III in 1888.

The old Transfiguration Cathedral was closed on March 11, 1930, and demolished on April 2, 1934. The new cathedral was closed on February 9, 1938, and repurposed as a city theater. It was reopened in April 1947.

In 1960, the cathedral building was demolished due to the construction of a bridge over the Cheptsa River. In 2006, an altar of the Ascension was added to the old church building in Glazov. Currently, the building, which previously housed a cinema and a sports school, is being reconstructed and will become part of a new church complex. The project was developed by the Kirov workshop "Anfilada." The reconstruction is being carried out with the support of the Board of Trustees and donations.