The Znamensky Cathedral in Tyumen, one of the oldest and most beautiful Orthodox churches in the city, impresses everyone who sees its architecture for the first time. It houses the chair of the Metropolitan of the Tobolsk Metropolis, His Eminence Dmitry, who is the rector of the cathedral. From the early 2000s until 2008, the cathedral was the center of the Tyumen diocese, covering Tyumen and several districts.

The cathedral is located at Semakova Street, 13, previously known as Podaruevskaya. It is an example of construction from different periods, executed in a unified style. The construction lasted nearly 150 years, and the exact date of the church's founding in honor of the Icon of the Mother of God 'Sign' is unknown, fluctuating between 1624 and 1659. The first wooden church burned down in 1697, was restored, and was again destroyed by fire in 1766. In 1768, a stone church was laid in its place, with the main stages of construction completed by 1786.

The first stone church included a porch with columns, a narthex with a bell tower, a refectory, and the main temple. The refectory housed a warm chapel of St. John Chrysostom, where services were held in winter, while the main temple was used in summer. The roof, dome, and fence were wooden. The bell tower had two tiers, with an icon of the Last Judgment in a round window. In 1837, the icon was replaced with the icon 'Sign.' Local masters E.K. Solomatov and F.I. Cherepanov participated in the writing of the icons.

In 1850, a reconstruction plan for the church was approved, which provided for its expansion and conversion into a warm church. The work was financed by merchant I.V. Ikonnikov. From 1851 to 1862, the northern chapel was dismantled, and a southern one was built, which burned down at the end of the 19th century. A garden was also planted in the churchyard, and in 1880, the wooden floor was replaced with cast iron.

In 1901, with funds from merchant M.I. Ivanov, two chapels were added to the church, and in 1904, the northern chapel was constructed, and the bell tower was increased. Today, the cathedral is a complex yet cohesive structure in the style of Russian Baroque.

The Znamenskaya Church played an important role in the spiritual education of Tyumen. By the first half of the 19th century, the city had a county school and two parish schools. By 1917, the parish had a women's gymnasium, a higher primary school, and a parish school.

In 1913, the church was renamed a cathedral, but it was closed in 1929. From 1930 to 1944, the building was used as a prison and an MTS. In 1965, a metal fence was installed around the cathedral, which caused discontent among the authorities.

The main shrine of the cathedral, the Icon of the Mother of God 'Sign,' has been venerated as miraculous since 1852. The first miracle is associated with a cholera epidemic in 1848 when the icon was carried around the city, and the disease receded.

In 1992, four bells from Far Eastern lighthouses were brought to the cathedral, two of which were installed in Tyumen, and two in Tobolsk. In 1994, the tradition of processions was revived, and in 2002, 12 new bells were installed on the belfry. In 2003, the domes and crosses were replaced, and the restoration of the cathedral continues.