In the 1820s, cholera ravaged the Kozelsky district. According to a legend preserved among the peasants of the village of Klykovo, during the epidemic, the Image of the Savior from the neighboring village of Kurinichi was brought to Klykovo. With a procession, it was carried around the village, and the disease, which had claimed many lives, gradually began to recede, and by August 16, it had completely ceased.

In gratitude to the Savior, the owner of the village of Klykovo, Guard Lieutenant Alexander Fedorovich Poltoratsky, built a new stone church in honor of Saint Nicholas on the site of the old wooden church. The construction was completed in 1829, and at his request, the church was consecrated in honor of the Lord Jesus Christ and His Not Made by Hands Image.

In 1924, after the devastation of the Holy Vvedensky Optina Monastery, part of the brotherhood settled in Klykovo, and the local church became the center of the community's spiritual life. From 1925 to 1935, the Optina hieromonk Panteleimon served here, of whom little is known: he was a skete monk, ordained a hierodeacon in 1916, and a hieromonk after the revolution.

In 1937, the church was closed. In the spring of 1991, it was returned to the Church, but the building was in a deplorable state: almost nothing remained of the interior decoration, the floor was destroyed, the walls were filled with dirt and debris, the ceilings began to collapse, and grass and trees were growing on the roof.

Archbishop Clement of Kaluga and Borovsk blessed the establishment of an Archierarchical Courtyard in Klykovo by the brotherhood from Optina Monastery. On January 11, 1993, the Archierarchical Courtyard was formed at the church, and on October 18 of the same year, Hieromonk Peter (Baraban) became the rector. A monastic community began to form, and on July 17, 2001, the Holy Synod decided to open the men's monastery of the Savior Not Made by Hands in Klykovo.

With the transfer of the church, restoration work began. The church built by Poltoratsky was fully restored by 1999, and on November 28 of the same year, Archbishop Clement consecrated its central altar.