The Spaso-Transfiguration Cathedral is a significant monument of pre-revolutionary Uglich, with a history that dates back to the times of the principality. The modern building of the cathedral, erected in the 18th century, stands on the site of an older wooden church, from which the parish originates. The first church at this site was built by Uglich prince Andrei Vasilyevich, known as the Great, the son of Grand Duke of Moscow Vasily II. He left a notable mark in history, although his fate was not easy. Initially, he received vast territories, but later fell out of favor with his brother, Grand Duke of Moscow Ivan III, was summoned to Moscow, and died in captivity.

The stone Spaso-Transfiguration Cathedral began construction in 1710, more than two hundred years after the death of the founder of the wooden church. The funding for the construction was provided by local wealthy residents, and the work was carried out by craftsmen from Yaroslavl. The church was built in the classical style, with five domes located at the center of the building. In 1730, a tall bell tower was constructed nearby, and a portico was added a hundred years later. The interior walls were painted only in the early 19th century under the guidance of the talented artist Timofey Medvedev, a serf of Prince Golitsyn.

During the Soviet era, the cathedral suffered greatly, but now its appearance has been restored, and it is in better condition than many other church buildings in the Yaroslavl region.