The Russian church in Wuhan, also known as 俄国阿列克桑德东正教堂, was built in 1893 in the Hankou district of Wuhan. It was dedicated to Saint Prince Alexander Nevsky and erected thanks to the efforts of Russian orientalist P.A. Dmitrievsky on land that previously belonged to the British and then the Russian Concession. At that time, trade between Russia and China was actively developing, especially among tea merchants who imported tea from Hankou and the northern part of Hunan province, where a large tea plantation still exists. The temple was built with the funds of these tea merchants. Despite the events of 1917 and the closure of key Russian factories, by 1930 the Russian colony in Wuhan remained prosperous, though small in number. The main tea merchants covered all the expenses of the church. It is known that there was a merchant hierarchy in the parish that determined the order of approaching the cross and the distribution of seats. After the service, everyone would head to continue the feast at the home of one of the tea plantation owners, Mrs. Litvinskaya. By 1950, the church had about 2000 parishioners from the local Chinese community, and a secondary school for Chinese children was also opened.

The church was closed in 1958. During the years of the 'revolution,' the building was used as a warehouse and later as a marriage palace. In 1998, it was included in the register of protected architectural monuments of the city. In 2013, the church faced demolition due to the construction of a tunnel under the Yangtze River, but thanks to efforts led by Patriarch Kirill of Moscow and all Russia, an agreement was reached to preserve and restore the building through joint efforts of Russia and China. In 2015, the House of Russian-Chinese Cultural Exchanges opened in the church, featuring an exhibition showcasing the spiritual culture of Russia and the history of Russian-Chinese relations.