In the 1890s, the construction of the Clinical Town of Moscow University was completed at Devichye Pole.

One of the key buildings of this complex is the Hospital Clinic, which includes therapeutic and surgical departments. It was built with state funds, laid down on September 22, 1887, and opened in 1892.

Initially, the Hospital Surgical Clinic of Moscow University was located at the Novo-Ekaterininskaya Hospital and was intended for training students in their 9th and 10th semesters, so they could familiarize themselves with the everyday work of a doctor.

The buildings of the surgical and therapeutic clinics on Bolshaya Pirogovskaya Street are almost identical and symmetrical, although each design is unique. The Hospital Clinic significantly exceeds the neighboring Faculty Clinic in area.

Both buildings are styled after Moscow estate constructions of the 18th century. The central part with the main entrance is adorned with a classical four-column portico, while the right and left wings consist of parts of different heights. The right wing houses the therapeutic clinic, while the left wing contains the surgical clinic.

A feature of the Hospital Clinic is the 'Large Operating Auditorium.'

Architect K.M. Bykovsky carefully designed the layout of the clinic. The first floor housed rooms for 'processing' patients, while the second floor contained hospital wards. The transitions between the buildings had a mezzanine third floor with apartments for staff.

The clinic included offices for professors and instructors, as well as spaces for scientific experiments and classes.

Bykovsky planned the flow of patients and students so that educational institutions were separated from hospital departments. The amphitheater principle was used for the auditoriums, and the corridors and classrooms were equipped with tall display cabinets.

It was here, in the Hospital Therapeutic Clinic, that A.P. Chekhov was brought on March 25, 1897. He wrote in one of his letters: '...in Moscow, I was unexpectedly delayed by hemoptysis and now I am lying in the clinic of Ostromov...'. At that time, the professor of the clinic was its founder A.A. Ostromov, an outstanding therapist who organized and equipped a scientific laboratory at the clinic back in 1884.

In 1982, a bust of the first People's Commissar of Health N.A. Semashko was installed in front of the main entrance to the former Hospital Clinic.

Currently, the building houses the Administrative Office of the I.M. Sechenov Clinical Center.