The small urban estate on Prechistenka has a rich history. In the 18th century, this area belonged to Colonel Y.Y. Protasov, and by 1752, stone chambers were already standing here, which were later expanded and rebuilt. These chambers have survived to this day and have become part of the modern building. In 1794, the property, occupying half a block, belonged to Princess S.I. Volkonskaya. From 1809, the plot passed to Moscow merchant Stepan Milyakov, and after his death, to his widow M.A. Milyakova. In the 1860s, the plot was divided into three independent properties. From 1892 until the revolution, the owners were the sons of merchant A.M. Istomin, Nikolai and Mikhail, who lived in apartments on the top two floors of the main house, consisting of 10 and 9 rooms. The lower floor apartment of seven rooms was rented out.

The address book "All Moscow" for 1915 contains information about the residents of the estate, including: Istomina Alexandra Nikolaevna, "Moscow Golutvin Textile Factory", cloth; Istomina Lydia Alexandrovna, "Khamovniki City Charity for the Poor"; Istomin Mikhail Alekseevich, Petersburg merchant of the 1st guild, board member of the "Golutvin Textile Factory Partnership", and after his father's death, director of the "Partnership", treasurer of the "Ladies' Charity for the Poor".

Alexandra Nikolaevna, wife of Alexei Mikhailovich, became a board member of the partnership after his death and donated 10,000 rubles in 1910 for the construction of a children's shelter. This was a significant amount, considering that a prestigious mansion cost about 30,000 rubles, and the royal family donated five thousand rubles a year for the needs of OSVOD.

In 1921, the partnership was renamed "Red Textile Worker". Mikhail Alekseevich continued to work at the factory until 1924 as treasurer, handling accounting.

After the revolution, the Istomins remained in their estate between Prechistenka and Gagarinsky Lane. The main house faced Prechistenka, where there was a front garden, a main entrance, and main gates. The fence and gate led to Gagarinsky. The carriage houses and a watchman's lodge adjoined house No. 6, which fell into disrepair in the 1920s, and the janitor settled in the basement of the main house, sharing it with another family. The Istomins occupied several rooms in the main house, where even the bathroom was converted into a living room. The study, library, and maid's room also became apartments. The Istomins were finally evicted after the war.

The carriage house was adapted for housing in the 1920s. It hosted notable people: artist Igor Grabar, Marina Tsvetaeva, poet Nikolai Aseev, and philologist Sergey Ozhegov. Sergey Ivanovich, having moved from Petersburg to Moscow, lived nearby on Smolensky Boulevard, and during the war, becoming the director of the Institute of Language and Writing of the USSR Academy of Sciences, walked to work daily through the Prechistenka alleys.

After the war, the carriage house changed owners. Since 1980, it housed the children's-parent club-workshop "Levsha". In 1995, part of the estate of merchant Istomin was purchased by a joint-stock company, the club was evicted, and the carriage house was demolished. Fortunately, the main house was not sold and has survived. Its eclectic-style facade with a balcony on the second floor remains part of the historical development of Prechistenka.