This house is located on Vozdvizhenka Street and has been preserved here since the late 18th century. In 1783, Prince Alexei Yakovlevich Shakhovsky built a two-story house with a mezzanine, wings, and grand gates leading to Kalashny Lane. Alexei was the youngest son of Prince Yakov Petrovich Shakhovsky, the Attorney General of the Holy Synod and the author of the famous autobiographical "Notes." His mother, Yevdokiya Yegorovna Lopukhina, was born a Faminitsyna. The house where Alexei grew up was nearby, at the Church of Boris and Gleb on Arbat Square.

Since 1842, the house has belonged to doctors. Initially, it was owned by the famous physician I.I. Krauze. In 1852, architect N.I. Kozlovsky remodeled the building when it belonged to staff captain Nikolai Yakovlevich Kozlakov. The changes mainly affected the facade and the interior. The first floor was allocated for shops, while the others were for apartments. The house acquired an impressive facade in the Rococo style, with semicircular lintels, pediments of the second-floor windows adorned with floral garlands, shells, and volutes. It became popularly known as "Rocaille."

In 1868, the estate was purchased by physician Dmitry Timofeevich Osipovsky. His father, Timofey Fedorovich Osipovsky, was a well-known scholar, professor of higher mathematics and astronomy, and rector of Kharkov Imperial University. In his later years, he moved with his family to Moscow and was buried at Vagankovo Cemetery. Dmitry graduated from the medical faculty of Moscow University and worked for a long time in various Moscow hospitals. In 1878, Dmitry Timofeevich Osipovsky was granted nobility, and the Osipovskys' coat of arms appeared on the pediment of the house.

Dmitry Timofeevich's wife had a niece named Elizaveta Grigoryevna Varenikova, a neighbor of A.P. Chekhov in Melikhovo. Chekhov mentioned her family in his stories "Gooseberries," "Neighbors," and "Three Years." In 1900 and 1917, Elizaveta Varenikova lived in this house with her cousin Dmitry Dmitrievich Osipovsky.