Since the late 17th century, the property behind the Myasnitsky Gates belonged to Lev Kirillovich Naryshkin, the uncle of Peter I. It is likely that in the early 18th century, stone chambers of rectangular shape were erected here. The plot was quite large for its time, extending to Bolshoy Kozlovsky Lane and combining the modern properties 44 and 46.

After the Naryshkins, the estate was owned for some time by G. F. Vishnevsky, and in 1749 it was acquired by P. Ya. Golitsyn. Presumably, under him, the house was rebuilt, as four years later its value significantly increased, as evidenced by the purchase agreement of the new owner F. V. Novosiltsev.

In the following years, the property frequently changed owners, and the main house was repeatedly rebuilt in accordance with architectural fashion and the wishes of the new owners. Additional estate buildings appeared.

In 1825, the estate was acquired by the secret advisor N. M. Arsenyeva. This period became one of the most interesting in the history of the mansion. It housed one of Moscow's cultural salons, attended by such notable figures as A. S. Pushkin, P. Ya. Chaadaev, M. I. Glinka, bibliophile A. A. Sobolevsky, writer N. F. Pavlov, historian and journalist N. I. Nadezhdin. The famous Hungarian composer Franz Liszt also often visited here and even lived in Arsenyeva's house for several days.

In 1847, the Arsenyevs sold the estate, and two decades later it was purchased by Baroness N. F. von Meck, the widow of Karl von Meck, a well-known railway magnate.

Nadezhda Filaretovna was a great lover of music and a generous patron. She was the first to recognize the talent of P. I. Tchaikovsky and supported him financially, allowing him to focus on his creativity. Although they never met, their correspondence lasted thirteen years. Tchaikovsky often stayed at her house on Myasnitskaya Street, but always in her absence. Their relationship ended in 1890 at von Meck's initiative due to her deteriorating financial situation.

Music was taught to von Meck's children by the young Frenchman Claude Debussy, who fell in love with Sonia von Meck and asked for her hand. However, Nadezhda Filaretovna refused him and asked him to leave the house. Debussy returned to France, where he became a famous composer.

After the death of N. F. von Meck, the house on Myasnitskaya was sold by her heirs to Nikolai Dmitrievich Stakheev, a well-known gold industrialist. Under him, an additional wing was built, and the property became profitable.

The last pre-revolutionary owner of the estate was Konstantin Fyodorovich Takhtamirov.

After 1917, the house became a communal dormitory. Later, the communal apartments were vacated, and various state institutions occupied the building. In the 2000s, restoration was carried out, and now this mansion, associated with the names of outstanding figures of Russian and world culture, is a decoration of Myasnitskaya Street.