The two-story stone mansion with a fence was built in the neoclassical style. The alley, which appeared on the map of Moscow in 1838, was named after one of the owners of the house, State Councillor and Senator Andrei Dashkov (1790, 1865).

The first mentions of the estate date back to 1816, when it belonged to Major General Yakov Merlin. The complex included the main house, several wooden residential wings, and outbuildings, which have not survived to this day. However, the white stone fence with metal gates and enclosures has survived and is now located between houses No. 5 and 7 on Dashkov Lane.

After Merlin, the estate passed to Andrei Dashkov. In the 1840s, his son Vasily Dashkov (1819, 1896), the future director of the Rumyantsev Museum in Moscow, which was located in the Pashkov House on Vagankovsky Hill, lived in the main house. It housed a rich collection of ancient manuscripts and books collected by Count Nikolai Rumyantsev. Andrei Dashkov's house also hosted his son-in-law, artist and vice-president of the Academy of Arts Prince Grigory Gagarin (1810, 1893).

After Andrei Dashkov's death in 1865, the mansion changed several owners, some of whom rented it out. During the Soviet era, the building housed communal apartments and the State Supply of the Kazakh SSR.

The house on Dashkov Lane represents not only memorial but also architectural value, being a typical example of residential development in Moscow in the early 19th century. The concise decorative design of the building reflects the features of neoclassicism. Inside, tiled stoves and a historical staircase have been preserved, and the floor of the first floor is laid with patterns made of Mettlach tiles. The main facade is adorned with a risalit featuring square half-columns and straight stucco cornices, while dormer windows are located on the roof.

In 2017, restoration work began on the house and its adaptation for modern use. A later wooden extension that covered historical window openings was dismantled, load-bearing structures were reinforced, the brickwork of the walls was restored, and the decorative finish of the facades was restored. The window openings were returned to their original sizes, and double joinery was installed, made according to 19th-century analogs.

Roof work included replacing the rafter system and covering it with roofing iron, as well as recreating the structure of the dormer windows. Restorers restored the stone porch of the main entrance and the white stone plinth around the house.

During the restoration, the historical layout of the building was returned with minimal changes for modern use. The interiors revealed and restored ancient tiled stoves, and the stone steps of the staircase were recreated based on the original samples.

The restoration was completed in February 2019. The house became a laureate of the Moscow Government competition for the best project for the preservation and popularization of cultural heritage sites "Moscow Restoration, 2019." It now houses a children's department of a medical center.