The house on Tverskaya Street, owned by first guild merchant Simonov, has been known since 1767. In 1778, a third floor was added for D.I. Naryshkin, preserving the early classicism style. In 1787, the building was acquired by Matvey Vasilyevich Dmitriev-Mamonov, president of the Land College. His son Alexander was a favorite of Catherine II. In 1812, the house belonged to Count Matvey Alexandrovich Dmitriev-Mamonov, the only son of the favorite.

Matvey Alexandrovich (1790, 1863) participated in the Moscow militia, in the battles of Borodino, Tarutino, and Maloyaroslavets. He created a volunteer regiment at his own expense and became its chief in 1813 with the rank of major general. During the French occupation, Prince Eugene Beauharnais, Napoleon's stepson, lived in his house.

Prince Eugene's Italian corps entered Moscow via Tverskaya Road, and the Mamunov house became the first significant building on their way. The Italians settled in the vicinity and likely saved several blocks from fire from Tverskaya to Patriarch's Ponds. The Mamunov house also remained unharmed by the fire.

After the war, Count Mamonov's fate turned tragic: he founded the pre-Decembrist circle 'Order of Russian Knights,' refused to swear allegiance to Nicholas I, and was declared insane. In 1830, his guardians sold the estate to the state Eye Hospital, which still occupies this building. The alley leading to the estate retained the name Mamunovsky.

In the 1880s, the corner parts of the house were raised to the level of the central part. In 1941, the building was rotated 90 degrees and moved to the alley on a new foundation with a basement, resulting in the central entrance arch becoming two stories high.