The building is designed in the style of early provincial classicism with characteristic proportions, noted Alexander Filyaev, director of the department for the protection of cultural heritage sites. It was constructed based on one of the standard projects attached to the master plan of 1784. The main composition and the main facade of the house were created according to such projects; however, during the construction process, plans were often changed, elements from other projects were borrowed, and the number of floors and sizes varied.

At the turn of the 18th and 19th centuries, a two-story stone house and wooden outbuildings were erected on the territory of the Ilyinskikh merchants' estate. According to detailed land records within the city of Uglich from 1852-1853, the property belonged to the merchant Elizabeth Karamysheva. In the early 20th century, house No. 16 was divided into two parts: two-thirds passed into the ownership of the Uglich Spaso-Preobrazhensky Cathedral, while one-third remained with the heirs of Elizabeth Karamysheva. It is likely that in the late 19th century, a two-story section was added to the building on the western facade.

The object is located in close proximity to the Epiphany Cathedral and plays an important role in urban planning, influencing the formation of the panorama of historical streets and the perception of the temple complex.

Currently, the building is used as a multi-apartment residential house.