The building, erected in the first third of the 19th century, was a meeting place for members of the secret revolutionary "Ishutin Circle" until 1866, led by Nikolai Ishutin, a cousin of Dmitry Karakozov, who was executed for an assassination attempt on Alexander II. The house is under state protection.

Ishutin actively developed revolutionary activities, uniting various circles in the cities of the Russian Empire. The main goal of the "Ishutin movement" was a peasant revolution, managed through a conspiracy of intellectual groups. The circles actively conducted propaganda among workers in factories and plants. By the beginning of 1866, a governing center called "Organization," a group named "Hell," and the "Society of Mutual Assistance" were established, which financed the movement. At meetings, members of the circle studied the works of Karl Marx and read Herzen's "The Bell." After Karakozov's assassination attempt in 1866, the organization was uncovered, and 32 members of the circle were convicted. Nikolai Ishutin was sentenced to death, which was commuted to life imprisonment.

In the late 19th century, the building was acquired by Colonel Tisheninov, and in 1898-1899, architect Sergey Mikhailovich Kalugin added to it and remodeled the facade in the style of academic eclecticism, which has been preserved to this day. The first floor housed various shops, while the upper floors contained offices and furnished rooms. It also housed the Society of Governesses for pedagogical courses in foreign languages and stenography, which existed until the early years of Soviet power. Apartments were rented for young teachers, and later a library and the Museum of the History of Pedagogy in Russia were opened. Leading Moscow educators participated in the society's work, including the first female astronomer in Moscow, Lydia Tsesar'skaya.

During the Soviet era, various trusts and communal apartments were located in the house. By the 1980s, the gradual resettlement of the building began. In the 1990s, one of the first large stores in Moscow selling audio and video cassettes was located on the first floor.

In the early 2000s, the attic space was reconstructed with the installation of windows on the courtyard facades and a change in the roof slope.

From 2006 to 2012, the building was not in use; in 2010, a fire occurred, leading to the collapse of the roof, parts of the ceilings, and stairs. In 2012, part of the facade on Arbat Lane was plastered with a hard cement mixture.

The complex of repair and restoration work according to the approved project was completed in 2013.

The first and second floors contain commercial non-residential premises. The historical layout and interior finishes in these premises have not been preserved.