In the late 19th century, a church was built in Tsaritsyn on Sennaya Square. The foundation stone of the building has been preserved, inscribed with: "In the name of the Father, the Son, and the Holy Spirit, this church is founded in honor and memory of the Exaltation of the Honorable and Life-Giving Cross of the Lord under Emperor Alexander III and Bishop Nikolai, in the year 7402 from the creation of the world, 1894 from the Nativity of Christ, on August 28." Initially, it was a wooden church, which was rebuilt into a stone structure in 1905 without demolishing the previous building.

In 1901, a one-story stone house was built on the church grounds, which housed the baptistery, prosphora room, choir rehearsals, and the residence of the priest and servant. The foundation of the church was shaped like a cross and was located where the children's rehabilitation center pool, school No. 130, and a vacant lot currently stand. The building, constructed in 1903 by Alexander Mikhailovich Shlykov, was designed by Professor D.I. Grimm from the St. Petersburg Academy of Arts, and the construction was overseen by provincial architect Yu. Terlikov. In 1912, the church had 2,183 parishioners, and a church school operated there. According to unconfirmed reports, Fr. Alexey Fyodorovich Mirandov and Fr. Dmitry Slavin served here. After the revolution, services continued. In December 1931, it was decided to remove the metal fence around the church. In 1932, the church fell into the hands of Renovationists and was temporarily closed, and in 1935, the bell tower was blown up.

According to archival data, services continued in 1936. On August 7, 1938, the presidium of the Stalingrad Regional Executive Committee decided to close the church, completing a seven-month process of its closure and transfer to the medical institute. The archives contain the case of the regional executive committee's commission regarding the church's closure, initiated on June 2, 1938, and completed on August 27. The building was transferred to the medical institute, and a garage and workshops were placed in the church. For some time, there was a room for corpses. The clergy house was handed over to the district housing department to organize the district military enlistment office.

During the Battle of Stalingrad, the church suffered significant damage, and in 1947 it was finally dismantled. Authorities feared that Archbishop Philip Stavitsky would demand the building be returned for repairs and reopening. According to other sources, the archbishop did request that the restoration of churches begin with this one, as it was in good condition. In 1947, a swimming pool was built in its place.

The clergy house in the Voroshilov district of Volgograd miraculously survived. It received minor damage and was repaired in 1943, after which a temporary school opened there. The images of St. Andrew's flags are still visible on the pilasters of the building. Over the years, various institutions have been located here: a seed station, a court, a housing and communal department, a fruit and vegetable office, and later commercial firms.

The question of returning the building to the parish was first raised in 1995. In 1999, the authorities returned one of the rooms to the believers, where services began, and in the fall of 2000, the deputies of the Volgograd City Council fully transferred the clergy house to the Exaltation of the Cross parish.

On June 10, 2014, the church was completely destroyed by fire. Currently, the foundation has been cleared, and fundraising for its restoration has begun.