In 1773, the Kazan Bishop granted the Mazunino residents permission to build a new stone church to replace the old wooden one. This event marked the beginning of the stone construction tradition in the Udmurt region. By 1782, the church was fully erected, at a time when there were no stone buildings in all of Udmurtia. In 1785, the chapel was consecrated, and ten years later, the main altar. However, it soon became clear that the 'warm church was quite cramped,' as, in addition to the Mazunino residents, people from surrounding villages also attended the church. In 1814, the construction of a new church began in Mazunino, which became a masterpiece of cult architecture in Udmurtia and a monument of European-level architecture.

The Vyatka bishop suggested simply expanding the old church, but the Mazunino residents decided to build a new, sturdy, and beautiful church, symbolizing the prosperity of their settlement on the banks of the Kama. Although it may seem disproportionate now, at that time it was believed that a wealthy village should have a large church. Mazunino then had 200 households, 1,800 residents, several mills, and developed crafts.

The church project was proposed to be built in Izhevsk, but it was considered too 'ornate' there, which did not deter the Mazunino residents, and they decided to construct it in their own village. The church, designed by the famous architect Semyon Emelyanovich Dudkin, became his most significant work in the Kama region. It was built in the shape of a 'Ship' and is visible from afar. In terms of the complexity and harmony of its stucco decor, the Mazunino church has no equal in Udmurtia. The iconostasis included 32 icons, and the walls were adorned with 20 paintings, the author of which is unknown. The floor was designed to resemble marble with gilding, and the church housed 10 bells. In the warm part of the church, there were two chapels: the right one was consecrated in 1821 in honor of the Kazan Mother of God, and the left one, in 1839, in honor of Saints Athanasius and Cyril. The main altar in the cold part, of the Transfiguration of the Lord, was consecrated in 1846. Unfortunately, photographs of the former splendor of the main altar have not survived.

In 1936, the church was closed and used for storing grain and fertilizers. In 1998, Archpriest Viktor Dmitrievsky, with the blessing of Archbishop Nikolai of Izhevsk and Udmurtia, began restoration work, organized community clean-ups and repairs, and resumed services.

In 2006, by the decree of the President of Udmurtia A. A. Volkov, restoration of the church's exterior was carried out. Restoration work continues, and soon the installation of the iconostasis in the left chapel, consecrated in honor of Saints Athanasius and Cyril, is planned.