The village of Bolshie Veski was formerly part of a palace volost, managed by Aleksandrovskaya sloboda, and was considered its settlement.

In the patriarchal tax records of 1628, it is mentioned: "The Church of the Nativity of the Most Holy Theotokos in the village of Veski, paying two altyns and two dengi."

By 1653, the Church of the Nativity of the Blessed Virgin Mary in the village of Veski had a priest's house, a prosphora-maker's house, and the parish counted 59 households.

In 1703, the church was served by priest Dmitry Ivanov, deacon Sergey Kondratiev, and prosphora-maker Kristina Leontyeva, and the parish had 133 households.

In 1724, permission was granted to build a new church on the site of the old one, and it was consecrated in 1727. In 1782, the wooden church burned down, and Bishop Theophilact of Pereslavl allowed the parishioners to transport the wooden Ilyinskaya church from Pereslavl and build it in Veski with the addition of new logs.

In 1819, the construction of the current stone Church of the Nativity of the Blessed Virgin Mary began with funds bequeathed by merchant Praskovya Ivanova. In 1821, the refectory church was completed and consecrated in 1822, while the main altar was consecrated in 1830. At that time, a stone bell tower was also erected. The church had two altars: in the cold part, the Nativity of the Blessed Virgin Mary, and in the warm refectory, the chapel of the Holy Unmercenaries Cosmas and Damian. The church housed a locally revered icon of the Sign of the Blessed Virgin Mary depicting the Great Martyr Theodore Stratilates and St. John Climacus. The icon bore the inscription: "In the year 1694, on the 1st day of April, Elder Tit of Lukyanov's desert built the image of the Blessed Virgin Mary in the House of God in the village of Veski."

During the Soviet era, the church was desecrated, and the bell tower and porticos on the southern and northern facades of the church were destroyed.