The stone church in Neklyudovo was built in 1800 with funds from Matryona Ivanovna Tuluzakova, the wife of a state councilor. The church had three altars: the main one was dedicated to the Nativity of Christ, the right side altar to the beheading of Saint John the Baptist, and the left to Saint Nicholas the Wonderworker. In the 1930s, during the persecution of the church, the church was closed for worship.

In the 1970s and 1980s, the building was used by the Neklyudovsky state farm as a warehouse. Currently, efforts are being made to restore the church. The stone Nativity church in Neklyudovo is an outstanding example of provincial classicism.

The church, located in the center of the village's main street, was built according to a traditional longitudinal-axial scheme. The five-domed church with a narrow rectangular three-part altar was adjoined by a small refectory and a two-tiered bell tower. The modern cupolas appeared later.

The square base of the church, covered by a high four-pitched roof, supports five widely spaced cylindrical drums topped with onion-shaped domes. The central dome is set on a solid wide drum. The drums of the side domes, pierced with small round windows, stand on cubic bases with semicircular openings at the bottom. The massive bell tower with tiered square sections, decorated with pediments, is topped with a low dome and spire.

The main building material of the church is red brick, while white stone is used in the details of arches, keystones, entablatures, and pilasters. Wooden elements include doors, floors, window frames, and the rafter system, while iron is used for wrought crosses, bell holders, window grilles, hinges, door hinges, roofing, and internal wall ties.

The dimensions of the church are 39 by 14.5 meters. The exterior of the building is plastered. The facade decor features a strict and restrained pattern with high-quality execution. The walls of the church are topped with an elaborate entablature, creating a rich play of light and shadow, and consist of a profiled cornice and frieze with brackets and rosettes. The corners of the church are adorned with pilasters of the Doric order. Paired pilasters highlight the central part of the side facades, which have three axes with large rectangular windows accented by archivolts with keystones. Pilasters are also located in the intercolumniations.

The side facades are marked by small rectangular windows with niches above them. The central part of the eastern facade is highlighted by pilasters and accented by a triangular pediment with dry bricks.

Both tiers of the bell tower are designed as pilastered porticos with pediments. Round windows are located between the tiers. The ringing tier is pierced with arched openings, while the arched openings of the first tier, except for the entrance, are false. The central space of the church, square in plan, is covered by a high four-sided vaulted ceiling. The three-part apse, whose width corresponds to the width of the church, is covered by three cross vaults and connects to the church through arched openings. The western part of the church, a wide space, is also covered by three cross vaults.