The Church of St. Sergius of Radonezh, located in Bad Kissingen, belongs to the Berlin and German Diocese of the Russian Orthodox Church Outside Russia. The idea of creating an Orthodox church in Kissingen arose as early as 1846 when Prince I. L. Goleniщев-Kutuzov gathered some funds for its establishment. However, the prince's illness hindered the completion of the project.

In 1857, when a visit from Emperor Alexander II was expected, the city authorities decided to gift a plot of land for the construction of the church. However, since the visit did not take place, the deed was returned. During subsequent visits by the emperor in 1864 and 1868, a chapel was arranged in his quarters.

The idea of building a separate church was proposed by Archpriest Alexiy Maltsev, and in 1897 the magistrate helped acquire a plot. The laying of the church took place on July 20 (August 1) 1898 under the guidance of Metropolitan Joseph (Georgian). The project was developed by V. A. Schröter, and construction was supervised by K. Kampf with funds from the Holy Vladimir Brotherhood. The chairman of the construction committee was A. P. Izvolsky.

On July 5 (18), 1901, the metropolitan consecrated the church in the name of St. Sergius of Radonezh. Services were conducted during the summer period by clergy from Berlin, Coburg, Weimar, and Stuttgart. With the onset of World War I, the church was closed, and its bells were melted down. The first post-war service took place on June 10, 1921, under the leadership of Archbishop Eulogius (Georgievsky). Since 1926, the church has been part of the Berlin and German Diocese of the Russian Orthodox Church Outside Russia.

In 1938, regular services were resumed by Priest Andrei Lovchiy, and the parishioners included Russians, Bulgarians, Romanians, Serbs, and Greeks. During World War II, the church served as a place of comfort for Soviet prisoners of war. In July 1945, the church became the cathedral church of Bishop Alexander (Lovchiy). The parish consisted of 150 to 200 people. Archpriest Alexander Bogachyov, the rector of the church in 1944 and 1946, helped Russian refugees avoid repatriation to the USSR. He passed away in 1946 and was buried in the city cemetery.

After 1950, the number of parishioners decreased, making it impossible to maintain a separate clergy. Minor repairs were carried out in 1960, 1961, and 1974, while major renovations were completed in 1998 for the church's centenary. From 1964 to 1996, the church was served by clergy from Nuremberg-Erlangen and Munich. In 1983 and 1995, Valentina Nikolaevna Kessel-Ganiyar and her husband supported the church by attracting tourists.

Today, between 80 and 130 parishioners attend Sunday services at the church.