The stone Nicholas church in the village of Pyskor, Usolsky District of Perm Krai, was built in 1695 with funds from salt industrialist Grigory Shustov. It served as the church of the Pyskor Spaso-Transfiguration Monastery, which was founded in 1560 by Ioanniky Fedotovich Stroganov and his sons. The first stone church of the monastery, dedicated to the evangelist John the Theologian, was laid around 1675.

It is believed that the Nicholas church was converted from the monastery's refectory. This viewpoint was supported by V.N. Shishonko, who claimed that only the refectory church with icons and a sacristy remained from the monastery. In 1755, the monastery was moved to the Lyssva River, the old buildings were dismantled, and the Nicholas church remained in its original location, becoming a hospital church and later a cemetery church. In 1831, it was converted to a church of the same faith.

The church is a rectangular cube with chapels, one onion-shaped dome, and an altar semicircle. Its decor is done in the spirit of Moscow architecture. In the 1830s, a refectory with a warm chapel of the Annunciation of the Blessed Virgin Mary was added to the church, as well as a narthex with a four-tiered octagonal bell tower topped with a spire. The bell tower has four openings for bells and is adorned with a Doric portico and small pilasters.

Particular attention in the Nicholas church is given to the facades of the cube and the altar apse. The windows are arranged in pairs over two floors: on the first floor, they are rectangular with an arched top, without relief decorations, while on the second, they have lush frames and a multi-tiered kokoshnik. In 1850, a five-tiered iconostasis was installed in the church.

In 1929, the church was closed, but it reopened in 1943. In the mid-1950s, partial restoration was carried out, but in 1962, the church was closed again.

Today, the Church of Nicholas the Wonderworker in the village of Pyskor is not functioning and is in a dilapidated state. Restoration work began in 2005, and in June 2006, the church was transferred to the Perm Theophany Men's Monastery, where plans are being made to create a monastery courtyard.