The village of Nikulsk, previously known as Mikulsk, was transferred by the Shuysky princes to the Trinity-Sergius Monastery in the early 17th century. In 1764, after the liquidation of the monastery's possessions, it became part of state property.

The church in the village has existed since the early 17th century. The land registry books mention that there was a wooden church in Mikulsk dedicated to St. Nicholas the Wonderworker, with a tented roof, deesis, royal doors, local icons, vestments, books, and an iron bell, built by the monastery. According to the land registry books of 1653, the parish had 86 households, and in 1703, 184 households. In 1726, the church burned down, and in 1729 a new wooden church was built in its place, purchased from the village of Lychenitsy. In 1799, the church burned down again but was restored in the same year; the wooden bell tower survived.

In 1822, a stone church was built with the funds of the parishioners, which still exists today. It has two altars: a cold one in the name of St. Nicholas the Wonderworker and a warm chapel in honor of the Protection of the Holy Virgin. The church is well-equipped with utensils, a sacristy, holy icons, and liturgical books. Among the relics is the cap of St. Moses the Ugrian.

Church documents have been preserved: copies of the metric books since 1796, confession lists since 1824. The church staff includes a priest and a psalmist. Their salary amounts to 650 rubles per year, including interest from capital, income from land, and services. The priest's house is church-owned, while the psalmist has his own.

The church's land holdings include 3 dessiatinas 1564 square sazhens of homestead land, 47 dessiatinas 1090 square sazhens of arable land, 7 dessiatinas 2020 square sazhens of haymaking land, totaling 58 dessiatinas 2274 square sazhens of unusable land. In 1886, 19 dessiatinas 281 square sazhens of land were bequeathed to the clergy. The priest's land is cultivated by peasants for free. The parish includes the village of Nikulsk, the hamlets of Bezmina, Berezovka, Afanasovo, and the village of Pogost, where the clerical records list 406 men and 463 women, all Orthodox. A literacy school operates in the village.