The village of Makaro was founded in the first half of the 18th century and became the site of the estates of first-guild merchant Khokhlov, as well as landowners Lovin and Shevelev. In 1803, a church was built here with altars: the main one in honor of the Kazan Icon of the Mother of God and in the refectory in the name of Saint Nicholas the Wonderworker.

The church in the village of Makaro, Balashov district of Saratov province, made of stone along with a bell tower, was erected in 1803 thanks to the efforts of the parishioners. The church had two altars: the main one in the cold part was consecrated in honor of the Kazan Icon of the Mother of God, while the warm refectory housed the Nikolsky chapel. The clergy included a priest, a deacon, and a psalmist, who lived in church houses.

In the village and in the village of Otradino, owned by landowner Orlova, church schools operated. Also, according to some data, there were zemstvo and ministry schools in the village. Three chapels were associated with the church: one two versts from the church at a spring, another at the Makaro cemetery, and the third in the village itself, on the site of a church that burned down in the 18th century.

On September 21, 1934, the Presidium of the Saratov Regional Executive Committee terminated the agreement with the believers of the village of Makaro, which likely led to the closure of the church. In the 1920s, the residents of the village and surrounding villages joined the collective farm 'Giant'.

The church building has survived to this day in a heavily altered state: the bell tower and domes have been demolished, and it is almost in ruins. However, according to researchers, its restoration is possible. Services in the church have not yet resumed.