The church in honor of the Kazan Icon of the Mother of God, also known as the Mother of God Church, was laid on May 24, 1815, in the settlement of the Lower Iset Factory, which is now located in the Chemash microdistrict. Before this, from July 12, 1809, a wooden Ascension Church, moved from Yekaterinburg, operated in the settlement. In September 1824, the building church was visited by Emperor Alexander I, who, according to legend, personally forged two nails and a hatchet at the factory. In 1837, the future Emperor Alexander II, then still the heir, also visited the Lower Iset Factory and the church during his journey across Russia.

On July 8, 1840, Bishop Evlampiy consecrated the church, and it became the main parish church of Lower Isetsk. The church had two chapels: the southern one dedicated to the Apostle and Evangelist John the Theologian, and the northern one in the name of Saint Stephen of Perm.

On March 1, 1909, the Lower Iset branch of the Aramil Church Society of Sobriety opened at the church, which had 146 members by 1911, while the parish had more than three and a half thousand people. In 1935-1936, the church was closed by the Soviet authorities, although the exact date of closure is unknown; it is assumed that this could have happened in 1946. During the Soviet era, the building was used as a children's home club, a Chemash factory club, and a factory workshop, and then remained empty for a long time.

On June 20, 1974, the church was blown up.

On April 5, 2002, Archbishop Vikentiy consecrated the cornerstone, and the restoration of the church began. On July 21, 2004, for the first time in many decades, a Divine Liturgy was held at this site. Since June 2011, regular services have been conducted in the church.