The almshouse with a chapel in honor of the icon of the Mother of God "All Who Sorrow Joy" was founded in 1861 by sisters from the Diveyevo convent, widow Shishkina and maiden Varvara Alexandrovna Karamzina, who were serving in the hospital.

The "Review of Churches of the Nizhny Novgorod Diocese" in 1886 reports on Bishop Modest's visit to this church. He visited the hospital church, consecrated on September 11, 1862. The church is not a separate building but occupies part of the wing where elderly nuns live. After visiting the church, the bishop also visited the cells of the eldresses, among whom were those who received a blessing from Seraphim, the founder of the convent. Of the 17 such eldresses, some lived here, while others were in another wing. Among them was Anna Alexeyevna, the last of the eight original founders accepted by Seraphim from the community of nun Alexandra. Varvara Alexandrovna Karamzina, the niece of historian Karamzin, expanded the church at her own expense. The bishop blessed the inhabitants of the cells.

According to the memories of nun Serafima Bulgakova, the windows of two cells adjacent to the altar allowed sick elderly women to pray right from their rooms.

The last service before the closure of the convent took place in this church on September 27, 1927, on the feast of the Exaltation of the Holy Cross. After the Divine Liturgy, the singers performed "The Lament of Adam," and all the sisters said goodbye, weeping.

During the Soviet era, the church was destroyed, and the cells were used as apartments. In 2003, the building was returned to the convent, and reconstruction began. On November 12, 2004, Bishop Georgy consecrated the cross that was installed on the dome of the church. The consecration of the church took place on November 6, 2006, on the feast day of the icon of the Mother of God "All Who Sorrow Joy."