The church in honor of St. Dmitry Prilutsky was built with funds from Moscow merchant Dmitry Petrovich Storozhev on the grounds of the Pathological Anatomy Institute at the Imperial Moscow University.

Construction of the clinical town at Devichye Pole began in the 1880s. The first chapel in honor of St. Dmitry Prilutsky appeared in 1890.

Later, the well-known Moscow philanthropist D.P. Storozhev approached the university administration with a request to build a church on the site of the chapel. Storozhev owned a house on Bolshaya Tsaritsynskaya Street (now Bolshaya Pirogovskaya), opposite the university clinics. He was a member of the council of the Alexandrovskaya Hospital of the Moscow Merchant Society and a trustee of the Solodovnikov Charity House.

With his donation, he wanted to "give poor people the opportunity to bury their deceased relatives at the University clinics after the liturgy, without requiring a specific fee for it." This was how he expressed his wish in a letter to the university rector.

However, Dmitry Petrovich did not live to see the start of construction. The church was built a year after his death. Before his passing, he entrusted his nephew Sergey Petrovich Sotvorenko to complete the initiated project.

The design of the new church was developed by architect B. Kozhevnikov. The monumental building was executed in the Byzantine style, which may have been determined with the participation of the chief architect of the Clinical Town K.M. Bykovsky.

The church was consecrated on September 25, 1903 (October 8 in the new style). After the revolution, the church was closed.

In the 1960s, the building housed a printing house, in the 1980s, a laboratory of anesthesiology of the 1st Moscow Medical Institute and an oxygen station, then a storage for used linen of the Medical Academy. In the 1990s, the Academy staff raised the issue of returning the church to the church, and a year later, services resumed.

This is the only altar in Moscow in honor of St. Dmitry Prilutsky. The church icon of St. Dmitry Prilutsky was painted in 1991 by a contemporary icon painter in the ancient Russian tradition. This saint, one of the outstanding ascetics, a prayerful intercessor and strict ascetic, was highly revered by our ancestors.

The church also houses relics of the holy healer Panteleimon and the venerated Theodorovskaya icon of the Mother of God.