The church dedicated to the holy prince Alexander Nevsky and the venerable Seraphim of Sarov is a Russian Orthodox temple in Liège, under the jurisdiction of the Archdiocese of Western European Parishes of the Russian Tradition of the Moscow Patriarchate.

In 1920, the children's orphanage of Elizabeth Kuzmina-Karavaeva moved from Constantinople to Liège, settling in the Jesuit building on Verbois Street, 13. With the funds from Cardinal Mercier, an Orthodox domestic chapel was established at the orphanage, with Archpriest Vladimir Fyodorov becoming its rector, the first permanent Russian Orthodox priest in Liège.

On January 21, 1922, the Russian Orthodox community was founded in Liège. After the orphanage and the rector moved to Brussels, on December 21, 1925, Priest Dmitry Troitsky was appointed to Liège from Berlin. Initially, local Catholics provided him with a prayer room, but soon there were "nitpicking, harassment, and attempts to convert to Catholicism."

The parish had to rent a private apartment and later use a former Catholic chapel owned by a music society. The iconostasis was obtained from the Nikolskaya Church in Brussels, and after each service, the icons and church utensils were stored "in a small closet under the stairs." Later, Dmitry Troitsky was succeeded by Sergey Sinkevich.

In 1931, Priest Valentin Romensky arrived in Liège after graduating from the Sergiev Theological Institute in Paris. Work began on creating a new church to meet the needs of the parish, which by that time had over a hundred Russian families. The municipality provided a building that had previously served as a storage for museum collections. The iconostasis and images were created by members of the Paris society "Icon": Major General Peter Fyodorov, Princess Elena Lvova, and Nun Ioanna (Reitlinger).

On December 16, 1944, the church was completely destroyed during German bombings.

Starting in 1948, fundraising began for the construction of a new church on a previously acquired plot of land. In the 1950s, Nikolai Tsygankov was the regent of the church. The design and construction of the new church were carried out by Nikolai Iscelennov, a member of the "Icon" society, a native of Irkutsk and a graduate of the School of Fine Arts in St. Petersburg.

On September 12, 1953, on the feast day of the church, Bishop Silvester (Kharuns) of Nice and Bishop Methodius (Kulman) of Campania, in the presence of city officials and numerous guests from Russian communities in Belgium, France, and Germany, as well as representatives of Catholic and Protestant communities, consecrated the church.

In 2009, Sergey Mudrov described the church as follows: "The multinational choir is precise and professional. The services are beautiful and moving. Especially pleasing was the frequency of services: all-night vigils on Saturdays, mandatory liturgies on major holidays, liturgies of the Presanctified Gifts during Great Lent. It was delightful to see that on the Feast of the Baptism, when the waters of the Volga are consecrated in Russia, the Dnieper in Ukraine, and the Neman in Belarus, the priest in Liège consecrates the waters of the Meuse River."