One of the oldest architectural complexes in Azov is the ensemble of the city hospital, founded in 1889 by the decision of the city Duma. The project was developed by engineer Sokolov, and the construction was led by merchant Syrovatsky. By 1898, two hospital buildings were erected on the outskirts of the city. Treatment at the hospital was paid, but there were five free beds named after Semyonkina, which she bequeathed to maintain with an annual amount of 5 thousand rubles. At that time, there were only two doctors in the city: the head of the clinic Fabian Natanovich Gurari and possibly the district zemstvo doctor Alexander Alexandrovich Kravtsov, whose name is mentioned in the metric book of the Alexander Nevsky Church.

By the end of the 19th century, the hospital was a small building with 20 beds, where outpatient services were also provided. By 1911, the Azov hospital had 10 male and 5 female wards.

After the revolution, the hospital buildings gradually fell into disrepair, and during World War II, they housed two military hospitals. Immediately after the war, the main transport in the hospital consisted of 4-5 discarded horses, a cart, and two wagons used to transport doctors and patients. Only in 1956 did the hospital receive its first ambulance with the opening of an emergency care point.

In September 1955, the Azov Central City Hospital became an independent institution with 135 beds, including 4 departments: surgical, therapeutic, maternity, and pediatric.

The modern appearance of the Central City Hospital was acquired in the 1960s. It included a polyclinic department with a clinical laboratory, X-ray room, physiotherapy department, children's polyclinic department, and health posts (medical and paramedic). The institution was located in buildings where the emergency department, cardiology department, and anti-tuberculosis dispensary are currently situated.