Andrei Mikhailovich Nosov (1814-1893) was one of the largest benefactors of Tambov region and made his fortune in livestock trade. His first charitable project was the opening of a city almshouse in Tambov in the late 1860s. This institution for men and women was created in collaboration with the merchants Ashurkov in the house of N. Kupriyanov on Dvortsovaya Street (now Soviet), opposite the Gostiny Dvor. At that time, Nosov, having exhausted his health with hard work, fell seriously ill and, realizing the fleeting nature of life, began to engage in charity. The almshouse was funded by the interest from his capital placed in the state bank and donations from the townspeople.

By 1872, Nosov built a stone church at the almshouse in honor of the righteous Lazarus. Initially, monks from the Tambov Kazan Male Monastery served there, and later a staff of a priest and a psalmist was created, for whom Nosov built houses. A church children's choir operated at the temple.

Later, stone buildings for a shelter for poor children (1889) were constructed, as well as a shelter for the incurably ill and a guest house where pilgrims could temporarily stay funded by donations. A boys' shelter for 40 children was also opened, which was soon expanded to 100. The boys were taught literacy and crafts until the age of 12-14.

An orphanage for girls was established at the almshouse for 100 girls, where they were taught literacy, handicrafts, and household management until the age of 16-17. Upon reaching this age, they received clothing and a small amount of money to start an independent life. Girls who got married received a dowry.

By the end of the 19th century, the almshouse had four stone buildings, a church, and other structures on a plot of 9780 desyatins. It housed 79 men and 261 women, 98 boys and 87 girls. In the guest house, 3541 people were registered as receiving lunch, and 6118 people spent the night with dinner in 1898. A free clinic and a hospital, opened on October 5, 1893, in honor of the Angel of the late Nosov, operated at the almshouse.

The almshouse existed until 1918, after which the building was used as city pharmacy No. 3 and the cinema "Komsomolets." In the late 1980s, the right wing of the building and the northern wall of the church collapsed. Restoration was initiated by a private individual, and in the 1990s, the building was returned to the Diocese thanks to the efforts of Bishop Eugene of Tambov and Michurinsk and Mayor V. Koval. The church began to be restored, and in 2010, new domes were installed.